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This sefking me onto a whole second area of interest. That interest led Pfaus to question a dogma he had been taught in school: But in male or female rats, you can associate a neutral odor with sexual reward, and animals change their behavior. And if you give a female rat one and only one male for her first, really rewarding experience, she will not only [subsequently] choose that male over [any] other, but she will mate-guard that male, but not other males, from competitor females. It turns out a simple Pavlovian procedure can redirect a sexual strategy.
Inhe found that although they activate different pathways, those pathways converge in regions of the hypothalamus and limbic system, including the nucleus accumbens core, pointing to that location as a processing hub for sexual stimuli. His team found that female rats that are treated with opioid-blocking drugs—and thus receive no opioid reward—during their first several sexual experiences later reject any males that try to mount them. That finding held true even for females primed with estrogen and progesterone, even though such animals typically solicit copulation with anything that moves. It seems that reward itself signals gene expression, and without that gene expression, your brain is not looking for a sexual reward.
Pfaus also uses his rats to test drug compounds for sexual effects. A company sends him a drug they want tested, and pays him to run a full double-blind trial, testing whether a drug increases the number of solicitations a female rat performs when she wants to copulate. When they broke the code [of the double-blind test], well, holy toot, it whoppingly increased solicitations. Of course, the drug was bremelanotide. They were going after estrogen or something that will keep estrogen bound.
They should be targeting excitatory systems directly: Dopamine controls sexual solicitation, and there are probably many ways into that system. Recently, Pfaus teamed up with Aaron Johnsona cognitive psychologist at Concordia, to extend his research to humans. People often think of autonomic arousal—things like vaginal, clitoral, and penile blood flow—as an indication of desire. Of course in men, penile blood flow and desire are generally concordant. Woman seeking sex in concordia is the only accredited domestic violence and sexual assault agency within its 10 county catchment area services services teen dating concordia office.
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